best sildenafil is a drug used to improve male sexual dysfunction. This drug acts on phosphodiesterase and is an inhibitor of phosphodiesterase. Generally, when encountering sexual stimulation, it can stimulate the release of local nitric oxide. Sildenafil can increase the guanylate cyclase in the cavernous body by inhibiting phosphodiesterase, relax the smooth muscle of the cavernous body, so that blood enters the cavernous body. Play a therapeutic effect to improve erectile dysfunction of the penis.
Specifications
Detail Information | |||
| CAS No.: | 171599-83-0 | Other Names: | Sildenafil |
|---|---|---|---|
| MF: | C28H38N6O11S | EINECS No.: | / |
| Type: | Pharmaceutical Intermediates, Auxiliaries And Other Medicinal Chemicals | Purity: | 99% Min |
| Application: | Auxiliaries And Other Medicinal Chemicals | Appearance: | White Powder |
| English Name: | Sildenafil Citrate | Grade: | Pharmaceutcial Grade |
| Packing: | 1kg/foil Bag | Molecular Weight: | 474.5764 |
| MOQ: | 1 Kg | Sample: | Availiable |
| Odor: | Characteristic | Test Method: | HPLC |
| Shelf Life: | 2 Years | ||
| Highlight: | C28H38N6O11S Sildenafil Citrate Powder, 474.58 Sildenafil Citrate Powder, Viagra Pill Powder For Erectile Dysfunction | ||
| Tests | Specifications | Result |
| Description | White or almost white crystalline powder | White crystalline powder |
| Solubility | Diffluent in Ach, slightly soluble in methanol, almost insoluble in chloroform | Complies |
| HPLC | Comply with standard | Complies |
| A292/A227 | 2.28~2.42 | 2.36 |
| IR | IR should comply with the reference standard spectrum | Complies |
| Citrate | Positive | Complies |
| Acidity | 3.0~5.0 | 3.63 |
| Loss on Drying | ≤1.0% | 0.32% |
| Residue on ignition | ≤0.1% | 0.04% |
| Heavy Metals | ≤10ppm | Complies |
| Relevant Impurity | ≤0.5% | 0.28% |
| Methanol | ≤0.3% | 0.02% |
| Methylene dichloride | ≤0.06% | 0.02% |
| N,N-Dimethyl formamide | ≤0.088% | Complies |
| Assay | 98.0~99.9% | 99.10% |
Function:
Erectile dysfunction (impotence) in adult males
Pulmonary arterial hypertension (in lower doses or as per protocol
PDE5 Inhibitor
Erectile Dysfunction Agent
Vasodilator for PAH (when used for that indication)
best sildenafil Viagra.It is a V-phosphodiesterase inhibitor, used to treat erectile dysfunction.
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Application
best sildenafil is a drug used to improve male sexual dysfunction. This drug acts on phosphodiesterase and is an inhibitor of phosphodiesterase. Generally, when encountering sexual stimulation, it can stimulate the release of local nitric oxide. Sildenafil can increase the guanylate cyclase in the cavernous body by inhibiting phosphodiesterase, relax the smooth muscle of the cavernous body, so that blood enters the cavernous body. Play a therapeutic effect to improve erectile dysfunction of the penis.
Other influence
BoolellM et al. conducted a study on a group of healthy volunteers, with doses ranging from 1.25 mg to 200 mg. Take it once a day, check the heart rate and blood pressure before and after taking the medicine, and keep blood and urine samples for analysis. the result shows:
1. Sildenafen is quickly absorbed by oral administration, and the plasma drug concentration reaches its peak within 1 hour after taking it;
2. The half-life of the drug is short, about 3-5 hours, and there is no obvious drug accumulation in one dose per day;
3. Using different doses from 1.25mg to 200mg, the average maximum plasma concentration and the area under the concentration-time curve will increase proportionally with the increase in the dose;
4. The average hourly plasma clearance rate is 41/L, the average stable volume of distribution is 105/L, and the average effective bioavailability of taking 50 mg sildenafil is 41%;
5. No obvious effect on blood pressure and heart rat
Mechanism of Action:
Sildenafil inhibits the PDE5 enzyme, which degrades cyclic GMP in the corpus cavernosum. This results in enhanced vasodilation, increased blood flow, and improved erectile function when sexual stimulation occurs.
Dosage & Administration:
For ED: 50 mg once daily, taken 30–60 minutes before sexual activity (dose may range from 25–100 mg based on response and tolerance).
Not to exceed single dose in 24 hours.
Sildenafil Citrate Powder Trade Information
Central America, North America, South America, Eastern Europe, Western Europe, Middle East, Africa
Baoji Hancuikang Bio-Technology Co., Ltd currently exports Sildenafil Powder to countries like Gulf Countries, South East Asia countries, African Countries, CIS Countries, LATAM countries, Central American Countries and in European countries.
Sildenafil Citrate is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), primarily used to treat erectile dysfunction and pulmonary arterial hypertension.
Pharmacokinetics:
Absorption: Rapid, with peak plasma concentrations reached within 30 to 120 minutes after oral administration.
Metabolism: Primarily hepatic via cytochrome P450 enzymes, mainly CYP3A4.
Elimination Half-Life: Approximately 4 hours.
Excretion: Mainly as metabolites in feces (approximately 80%) and urine (approximately 13%).
Indications
Erectile Dysfunction (ED): To improve the ability to achieve and maintain an erection.
Pulmonary Arterial Hypertension (PAH): To improve exercise capacity and delay clinical worsening.
Starting dose: 50 mg orally, as needed, approximately 1 hour before sexual activity.
Adjustable between 25 mg to 100 mg based on efficacy and tolerability.
Maximum recommended frequency: Once daily.
For PAH: 20 mg three times a day, taken 4 to 6 hours apart.
Adverse Effects: Common:Headache,Flushing,Dyspepsia,Nasal congestion
Dizziness:Visual disturbances (e.g., changes in color vision)
Serious: Sudden hearing loss
Non-arteritic anterior ischemic optic neuropathy (NAION)
Priapism (prolonged erection)
Hypotension
Contraindications:
Concurrent use with nitrates or nitric oxide donors.
Known hypersensitivity to Sildenafil or any component of the formulation.
Drug Interactions:
Nitrates: Potentiation of hypotensive effects; concurrent use is contraindicated.
Alpha-blockers: May lead to symptomatic hypotension; initiate Sildenafil at the lowest dose.
CYP3A4 Inhibitors (e.g., ketoconazole, ritonavir): May increase Sildenafil exposure; dose adjustments may be necessary.
OEM Services
Quality Assurance The quality of yohimbine hydrochloride greasepaint is of utmost significance. This not only ensures a dependable force but also allows for prompt order fulfillment.OEM Services In addition to offering a high- quality product, the company provides Original Equipment Manufacturer( OEM) services. This means that guests have the inflexibility to use their own branding and packaging, acclimatizing the product to their specific requirements.Fast and Secure Delivery Timely delivery and secure packaging are essential considerations for any product.
Storage:
Powder Form: Store below 30C (86F) in the original package to protect from moisture.
CONTACT US
With the concept of “Quality First, Integrity First”, Hancuikang Bio-Technology Co., Ltd. is strictly performing the standard in production and quality control of Sildenafil Powder. Independent laboratory and famous third-party retest confirm that each batch is qualified, so please do not doubt, and contact us by email: fxu45118@gmail.com or WhatsApp/Wechat:86+13379475662.
