Overview and Sources of Pterostilbene
Pterostilbene (PTS) is a naturally occurring stilbenoid compound, chemically similar to resveratrol, and considered the "next generation" of resveratrol due to its improved bioavailability with two methoxy substitutions. Its natural sources include blueberries, grapes (leaves and vines), almonds, heartwood of Pterocarpus species, etc., with blueberries being one of the most abundant food sources.
Chemical Properties and Preparation
Physical properties: A white crystalline powder that is sensitive to air, soluble in hot methanol and dimethyl sulfoxide (DMSO), but insoluble in water.
Chemical structure: Belongs to the trans-stilbene derivatives, with the molecular formula C₁₆H₁₆O₃, exhibiting antioxidant, anti-inflammatory, and other biological activities.
Preparation methods: Can be synthesized through Witting-Hornor reaction, reduction, diazotization, and hydrolysis, with a total yield of about 53.9%.
Specifications
process
Core Bioactivities and Health Effects of Pterostilbene
Pterostilbene has extensive pharmacological effects, mainly exerting its functions through antioxidation, anti-inflammation, and regulation of cell signaling pathways, including:
Antioxidant and Anti-inflammatory Mechanisms
Removing oxidative stress: Reduces the production of reactive oxygen species (ROS) such as hydrogen peroxide (H₂O₂) and superoxide anion (O₂⁻), while upregulating the expression of antioxidant enzymes (e.g., superoxide dismutase SOD, glutathione peroxidase GPx).
Anti-inflammatory pathway regulation: Downregulates the expression of iNOS (inducible nitric oxide synthase) and COX-2 (cyclooxygenase-2) genes, inhibiting inflammatory reactions and supporting connective tissue health.
Disease Prevention and Improvement
Anticancer activity
Inhibits P450 cytochrome enzymes (which can activate chemical carcinogens), reducing the risk of colorectal cancer and other cancers; animal experiments show that continuous intake of blueberries or grapes containing pterostilbene for 8 weeks reduces precancerous lesions in the colon by 57%.
Induces apoptosis in malignant cells, inhibits tumor cell spread, and may affect breast cancer cells through the regulation of estrogen receptor-alpha (ERα) signaling pathways.
Metabolic and cardiovascular protection
Lowers low-density lipoprotein (LDL) cholesterol, improves lipid abnormalities, and prevents heart disease.
Assists in regulating blood sugar, potentially improving diabetes and metabolic syndrome.
Neuro and cellular protection
Functions as a neuroprotectant, possibly enhancing cellular antioxidant defenses through the Nrf2-ARE (nuclear factor E2-related factor 2-antioxidant response element) signaling pathway.
Comparison with Resveratrol
Compared to resveratrol, pterostilbene has the following advantages due to structural differences (methoxy substitution of hydroxyl groups):
Better oral absorption: Methylation modification reduces liver metabolism and clearance, resulting in superior bioavailability.
Stronger activity at lower concentrations: Under equivalent concentrations, pterostilbene exhibits greater efficacy than resveratrol in anti-inflammatory and antioxidant experiments.
OEM Services
We offer OEM services for it. Our experienced team can customize the product according to your specific requirements, including formulation, packaging, labeling, and more. We understand the importance of branding and can help you create a high-quality product that aligns with your brand image.
Future Applications and Research Directions
Current research on pterostilbene is mainly at the stage of disease models and cell experiments. Future directions may include:
Functional foods and dietary supplements: Developing dietary supplements targeting cardiovascular health and anti-aging based on its antioxidant and metabolic regulation effects.
Clinical treatment potential: Further exploring its targeted treatment mechanisms in diseases such as cancer and diabetes, and promoting human clinical trials.
About Baoji Hancuikang Bio-Technology Co.,Ltd
Baoji Hancuikang Bio-Technology Co.,Ltd is a professional manufacturer and supplier of Pterostilbene. Our facility ensures high-quality production. We have a large inventory and offer fast delivery. Our products are backed by complete certifications, and we provide support for testing. If you are looking for your own Pterostilbene, please feel free to contact us.
